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CytoMed Therapeutics

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  • 上市
公司全称:CytoMed Therapeutics Ltd
国家/地区:新加坡/——
类型:肿瘤治疗药物开发商
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公司介绍:
CytoMed Therapeutics Ltd于2018年3月8日在新加坡注册成立。该公司是一家临床前生物制药公司,专注于利用该公司的专有技术创造用于治疗人类癌症的新型细胞免疫疗法。该公司新技术的开发灵感来自于现有CAR-T细胞在治疗血液恶性肿瘤方面的临床成功,以及将CAR-T原理应用于实体肿瘤治疗方面的当前临床局限性和商业挑战。

基本信息

成立时间:

2018-01-01

员工人数:

15~50人

联系电话:

65-62507738

地址:

1 Commonwealth Lane #08-22 Singapore 149544

公司官网:

www.cytomed.sg

企业画像
应用技术:
  • 治疗技术
  • 蛋白
  • CAR-T细胞治疗
  • 干细胞疗法
  • 细胞疗法
  • 免疫疗法
  • 融合蛋白
  • 生物制剂治疗
热门标签:
  • 创新药
  • 干细胞疗法
  • CAR-T细胞治疗
研发信息
靶点:
适应症:
治疗领域:

团队信息

CHOO Chee Kong ——
Chairman and Director 薪酬:——
个人简介:——
Lucas LUK Tien Wee ——
Chief Clinical Officer and Director 薪酬:——
个人简介:——
CHOO Chee Kong ——
Chairman and Director 薪酬:——
个人简介:CHOO Chee Kong,has been Cytomed Therapeutics Ltd Chairman since the incorporation of Cytomed Therapeutics Ltd Company in March 2018. Mr. Choo has over 20 years of experience in corporate finance. He is presently the executive vice chairman of CNMC Goldmine Holdings Limited (CNMC Group) which is listed on the SGX-ST (SGX-ST stock code: 5TP) since 2008 where he is responsible for the formulation of the strategic direction and expansion plans as well as the corporate governance of CNMC Group. He previously worked at DBS Bank Ltd of Singapore from 1986 to 2000. In the year 2000, Mr. Choo started his own corporate advisory and stockbroking boutique, Westcomb Financial Group Limited, which he listed on SGX-ST in 2004 (SGX-ST stock code: 5EC) and served as its Chief Executive Officer from 2000 to 2008. He served as an independent director at SGX-ST listed Second Chance Properties Ltd (SGX-ST stock code: 528) from February 2009 to November 2015 and SGX-ST listed FDS Networks Group Ltd (SGX-ST stock code: F07) from June 2008 to March 2015. He also served as a non-executive director at SGX-ST listed Advance SCT Limited (SGX-ST stock code: 5FH) from May 2012 to June 2015. He started his career in October 1981 as a Project Engineer with Esso Singapore Pte Ltd. Mr. Choo received a Bachelor of Engineering in Mechanical Engineering (First Class Honours) from University of Liverpool (United Kingdom) in July 1981 and a Master in Business Administration from the University of Bradford (United Kingdom) in December 1985.In October 2015, Mr. Choo, was publicly reprimanded by the Singapore Exchange for failing to disclose and seek shareholder approval for an interested party transaction which occurred in May 2012 where he was the non-executive director to Advance SCT Limited, the company in question, and also the 50% owner of CNCM Capital Pte Ltd, the other company party to the transaction. There were no fines imposed on him and as of the date of this Prospectus, he remains as an executive director of a SGX-ST listed company, CNMC Goldmine Holdings Limited (CNMC Group) (SGX-ST stock code: 5TP).On October 5, 2009, Mr. Choo was appointed as a non-executive director and chairman of Falmac Limited ("Falmac"), a company listed on the SGX-ST's Catalist Board when Falmac was being explored as a potential target for a reverse takeover. However, the reverse takeover exercise did not materialize and Falmac was delisted by the SGX-ST on August 22, 2011. Following the delisting of Falmac, Mr. Choo resigned as a non-executive director and chairman of Falmac on August 29, 2011. Subsequently in or around August 2013, a creditor petitioned to the Singapore High Court to wind up Falmac and the winding up order was granted on May 15, 2014.
Lucas LUK Tien Wee ——
Chief Clinical Officer and Director 薪酬:——
个人简介:Lucas LUK Tien Wee,has served as a member of Cytomed Therapeutics Ltd Board since January 2021 and as Cytomed Therapeutics Ltd Chief Clinical Officer. He has a keen interest in cellular therapy and has attended numerous certificate courses pertaining to clinical cell therapy. He is Cytomed Therapeutics Ltd designated Principal Investigator for Cytomed Therapeutics Ltd registered Phase I Clinical Trials in Malaysia, pertaining to Mesenchymal Stem Cell Therapy and CAR-T Cell therapy. Dr. Lucas also serves as a member of the Science Industry Advisory Committee for PSB Academy's School of Life Sciences (Singapore), since 2019. He is also the Medical Director and Consultant Obstetrician & Gynaecologist (O&G), and founding Chairman of the Independent Ethics Committee, at LMC, a private licensed hospital in Malaysia since 2019. As an advocate for women's health, Dr. Lucas has held the position of Secretary for the Royal College of Obstetricians & Gynaecologists (RCOG) International Representative Committee (IRC) – Malaysia, from 2018 until October 2021. He is also actively involved in medical education and has been on board the central planning and training committee for the Malaysian National MRCOG Parallel Pathway Programme for Malaysian doctors training in the specialty of Obstetrics & Gynaecology, since November 2017. He is an invited medical lecturer at Monash University (Johor Campus) since March 2021. Dr. Lucas received his M.D. MRCOG (UK) from Royal College of Obstetricians & Gynaecologists (United Kingdom) in 2016 and MB BCh BAO from Royal College of Surgeons (Ireland) in 2008, and has a Good Clinical Practice qualification.
ZENG Jieming ——
Chief Scientific and Medical Officer 薪酬:
个人简介:ZENG Jieming,is one of Cytomed Therapeutics Ltd scientific founders. He has served as Cytomed Therapeutics Ltd Chief Scientific and Medical Officer overseeing the product development and manufacturing as well as the clinical trial application since August 2019. Equipped with over 20 years of research experience and in-depth knowledge in the field, he has dedicated himself to translating the Company's platform technologies into clinical applications and therapeutics. Prior to joining CytoMed, he has been working as a research scientist in the A*STAR, Singapore from June 2004 until July 2019. He has been the key scientist of several research projects and the lead authors of 11 original research articles, for which he both carried out and led the research as well as wrote and published the papers. His research has been focused on developing efficient non-viral and viral vectors for gene therapy (Zeng, et al. J Gene Med 6: 1247, 2004; Zeng, et al. Biomaterials 26: 679, 2005; Zeng, et al. Biomaterials 28: 1443, 2007; Zeng, et al. Stem Cells 25: 1055, 2007; Zeng, et al. Molecular Therapy 17: 1585, 2009; Du, Zeng et al. J Biosci Bioeng 109: 1, 2010) as well as developing novel cancer immunotherapies from human pluripotent stem cells ("hPSCs"), including human embryonic stem cells ("hESCs") and induced pluripotent stem cells ("iPSCs") (Zeng, et al. The Journal of Immunology 188: 4297, 2012; Zeng, et al. Stem Cells Transl Med 3: 69, 2014; Zeng, et al. Scientific Reports 5: 15262, 2015; Zeng, et al. Stem Cell Reports 9: 1796, 2017; Zeng, et al. PLoS One 14: e02168152019). During his 15-year stint in A*STAR, he successfully generated dendritic cells for cancer vaccination and NK cells for adoptive cell transfer from hPSCs (Zeng, et al. The Journal of Immunology 188: 4297, 2012; Zeng, et al. Stem Cells Transl Med 3: 69, 2014; Zeng, et al. Scientific Reports 5: 15262, 2015; Zeng, et al. Stem Cell Reports 9: 1796, 2017). These hPSC-based immune cell technologies open a new frontier in the development of cell-based cancer immunotherapy. In 2017, he has invented an iPSC-based technology to produce a novel type of synthetic immune cells, gamma delta NKT cells to recognize and kill a wide range of cancers (Zeng, et al. PLoS One 14: e02168152019) and the technology has been licensed to Cytomed Therapeutics Ltd in 2018. Dr. Zeng received his Ph.D. from National University of Singapore (Singapore) in 2004 and M.D. from Sun Yat-Sen University (China) in 1996.

企业动态

新加坡生物制药公司CytoMed Therapeutics Limited(纳斯达克:GDTC)在2026年进入新的一年,公司专注于开发新型、经济实惠的供体来源的细胞免疫疗法,治疗多种癌症,包括血液和实体瘤。CytoMed通过其子公司LongevityBank正在开发临床级脐带血来源的自然杀伤细胞,以增强对稀有和有价值脐带血的获取,用于细胞疗法。公司还获得了新加坡企业发展局的支持,并计划继续资助其活动至少一年。CytoMed正在新加坡进行一项针对无治疗选择癌症患者的临床试验,并计划在2026年6月前向马来西亚当局提交新药申请。CytoMed还与德克萨斯大学MD安德森癌症中心合作,研究其γδ T细胞疗法在治疗急性髓系白血病(AML)方面的潜力。CytoMed还计划寻求股东对一项新方案的反馈,该方案允许股东使用其股份获得公司供体来源的同种异体未修改的γδ T细胞。
新加坡生物制药公司CytoMed Therapeutics宣布与马来西亚大学马六甲医学中心(UMMC)签订谅解备忘录,共同开展一项多中心、首次人体I期临床试验,以研究CytoMed的专利同种异体未修饰的γδ T细胞(CTM-GDT)在马来西亚无治疗选择癌症患者中的安全性和有效性。这一举措补充了CytoMed在新加坡国立大学医院进行的首次人体I期嵌合抗原受体(CAR)T细胞临床试验,该试验使用γδ T细胞工程化表达一种专有的CAR(CTM-N2D),旨在针对多种癌症,包括晚期结直肠癌、淋巴瘤、多发性骨髓瘤、肺癌、卵巢癌和肝细胞癌。CytoMed的主席Peter Choo表示,与UMMC的合作将为有限治疗选择的患者提供负担得起的癌症免疫疗法选项,并基于人体自然T细胞的天生能力来检测和杀死癌细胞。CytoMed的技术是同种异体的,意味着我们从健康供体中制造一种罕见的专业T细胞亚群,称为γδ T细胞,这种细胞在高纯度下生产,不会在患者中引起免疫排斥。与自体疗法相比,同种异体技术制造成本显著更低,物流更快、更简单,使患者更容易获得,包括海外患者。未修饰的γδ T细胞在国际临床试验中已被证明具有杀死癌细胞的潜力。CytoMed是2025年9月发表在研究文章“供体衍生Vγ9Vδ2 T细胞用于急性髓系白血病:一种有希望的‘现成’免疫疗法方法”的共同作者。该研究结果表明CytoMed的CTM-GDT在治疗急性髓系白血病方面具有巨大潜力。
新加坡生物制药公司CytoMed Therapeutics Limited(纳斯达克:GDTC)近日宣布已完成对TC BioPharm Limited(TCBL)的TCB-002同种γδT细胞技术的收购。TCB-002技术旨在治疗多种癌症,包括血液和实体瘤。该技术已在美国获得孤儿药资格认定,用于治疗急性髓系白血病。CytoMed计划利用这一技术在中国和印度进一步开发癌症治疗应用。公司还与潜在合作伙伴进行深入讨论,共同开发一种新的制造捐赠者来源的非修饰性同种γδT细胞的方法,该方法不使用活细胞,而是使用在中国可以低成本制造的细胞因子。此外,CytoMed的γδT细胞技术和相关嵌合抗原受体γδT细胞(CAR-γδT细胞)技术已获得中国国家知识产权局(CNIPA)的专利。
新加坡临床阶段生物制药公司CytoMed Therapeutics Limited(纳斯达克:GDTC)宣布,公司执行董事长兼重要股东Peter Choo通过近期公开市场购买,增持了公司105,824股股份。加上他个人持有的187,500股,Peter Choo在CytoMed的个人持股比例达到2.50%。此外,Peter Choo还持有Glorious Finance Limited 55%的股份和EP Capital Inc 100%的股份,合计持有2,388,246股,占公司总流通股本的21.95%。Peter Choo表示,他对公司独特的技术在亚洲,尤其是中国市场治疗癌症的潜力和价值充满信心。他认为,东南亚不断发展的医疗保健和医疗旅游生态系统,以及西方国家医疗保健成本的上升,为创新者提供了独特的机遇。CytoMed Therapeutics Limited成立于2018年,从新加坡领先的公共部门研发机构A*STAR分拆而来,专注于利用其授权的专有技术,如gamma delta T细胞和iPSC衍生的gamma delta自然杀伤T细胞,开发新型细胞免疫疗法。
新加坡临床阶段生物制药公司CytoMed Therapeutics Limited(纳斯达克:GDTC)宣布,已提交现金投标,对TC BioPharm Limited(TCBL)进行潜在收购。TCBL和CytoMed都是专注于研发供体来源的γδT细胞用于癌症治疗的临床阶段生物制药公司。CytoMed计划通过此次收购加强其在使用供体来源的细胞疗法治疗癌症方面的专业知识和技能,以加速其商业化进程,并为其使命——为全球患者提供负担得起的治疗方案——提供支持。CytoMed的主席Peter Choo表示,TCBL的γδT细胞疗法在临床试验中显示出良好的潜力,且成本效益高。此次收购预计将使用公司内部资源进行,具体信息将在适当时候公布。
新加坡生物制药公司CytoMed Therapeutics宣布其与德克萨斯大学MD安德森癌症中心合作进行的预临床研究已发表。该研究探讨了CytoMed的异基因γδ T细胞疗法(CTM-GDT)在治疗急性髓系白血病(AML)中的潜力。研究结果表明,该疗法有望成为治疗AML的一种有前景的“现成”免疫疗法。CytoMed计划在新加坡进行其领先产品CAR-γδ T细胞(CTM-N2D)的1期临床试验后,进一步推进其γδ T细胞疗法的研究。CytoMed成立于2018年,专注于开发基于细胞的新颖免疫疗法,用于治疗各种人类癌症。
新加坡生物制药公司CytoMed Therapeutics Limited与新加坡Sengkang General Hospital达成研究合作协议,旨在推进一种基于脐带间充质干细胞(UC-MSCs)的软骨再生疗法的临床研究。该疗法旨在治疗软骨损伤,包括膝骨关节炎,预计将在新加坡进行一期临床试验。CytoMed将提供UC-MSCs,而Sengkang General Hospital将提供基础设施、人力和数据分析。这项合作有望成为新加坡首个干细胞临床试验,并可能为软骨修复领域带来新的治疗选择。
CytoMed Therapeutics与杭州CNK Therapeutics签署合作协议,利用CNK的PiggyBac技术将CAR基因永久植入其γδT细胞,提高CAR-T细胞在体内的持久性。此举旨在增强CytoMed的CAR-T细胞疗法,使其在患者体内持续发挥作用,提高治疗效果。该合作是CytoMed在北亚地区多个合作努力中的第一个,并有望进一步推动其在中国的临床试验。
新加坡生物制药公司CytoMed Therapeutics宣布,其从新加坡科技研究局(A*STAR)独家授权的CAR-γδT细胞技术获得中国国家知识产权局颁发的专利。该技术旨在通过临床规模扩增少量供体外周血细胞的T细胞,并将CAR改造的T细胞用于识别多种癌症,包括实体瘤和血液瘤。CytoMed计划在2023年下半年开始进行CAR-T细胞的人体临床试验,并已招募首位血源捐赠者。该技术有望在免疫治疗领域,包括干细胞治疗中发挥重要作用。
新加坡生物制药公司CytoMed Therapeutics宣布,其从A*STAR独家许可的CAR-γδT细胞技术获得美国专利局授权。这项名为“γδT细胞及其增强肿瘤杀伤活性的方法”的专利,涵盖了从少量供体外周血细胞中临床规模扩增T细胞的技术,以及将扩增的T细胞修改为包含嵌合抗原受体(CAR),使修改后的细胞能够识别包括实体瘤和血液瘤在内的多种癌症。CytoMed拥有这项专利技术的全球独家使用权,用于免疫治疗,包括干细胞治疗,直到专利到期。CytoMed计划在新加坡进行CAR-T细胞的人体临床试验,并期待从其他地区获得额外的专利权。
CytoMed Therapeutics Limited与德克萨斯大学MD Anderson癌症中心合作,共同推进自体γδT细胞在癌症治疗中的应用,特别是针对急性髓系白血病(AML)和乳腺癌。该合作旨在开发新的治疗手段,以满足AML和乳腺癌患者的未满足需求,并降低治疗成本。研究将由MD Anderson的Leukemia副教授Venkata Lokesh Battula博士领导,将评估CytoMed的异体γδT细胞在AML和乳腺癌不同亚型中的体外和体内应用。研究将使用患者来源的AML细胞和乳腺癌细胞系进行。CytoMed已获得新加坡卫生科学局批准,开展其领先异体嵌合抗原受体T细胞(CAR-T)产品候选(CTM-N2D)的临床试验,该试验针对多种血液和实体肿瘤癌症,包括结直肠癌、肺癌、肝癌、卵巢癌、淋巴瘤和多发性骨髓瘤。

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2023-04-14

CytoMed Therapeutics Pte Ltd

肿瘤治疗药物开发商

医药研发/制造
化学&生物药

上市
——
——

2019-12-11

CytoMed Therapeutics Pte Ltd

肿瘤治疗药物开发商

医药研发/制造
化学&生物药

债权融资
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