ChiCTR2500113572
尚未开始
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2025-12-01
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Nephrotic Syndrome
Comparison of Effectiveness of Oral Furosemide-Metolazone Versus Oral Furosemide-Spironolactone Combination Therapy in Management of Refractory Edema in Children with Nephrotic Syndrome.
Comparison of Effectiveness of Oral Furosemide-Metolazone Versus Oral Furosemide-Spironolactone Combination Therapy in Management of Refractory Edema in Children with Nephrotic Syndrome.
54000
The aim of the study is to compare the effectiveness of oral furosemide-metolazone versus oral furosemide-spironolactone combination therapy in the management of refractory edema in children with nephrotic syndrome.
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Patients will be divided in two groups and recruited in the study through convenient sampling technique and then will be randomly assigned to each group according to consort guidelines 2010 by principle investigator. Written informed consent will be taken and will be allocated either to Group 1 or Group 2 by simple random sampling through sealed opaque envelope. Individuals in Group 1 will be given Oral Furosemide-Metolazone combination of diuretics. Individuals in Group 2 will be given Oral Furosemide-Spironolactone combination of diuretics.
Study medications should be packaged identically and labeled with participant ID only. Pharmacy (unblinded) prepares and dispenses; investigators, outcome assessors and participants remain blinded.
Hospital
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30
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2026-01-01
2027-01-02
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1. Children diagnosed with nephrotic syndrome with refractory edema or severe anasarca and not achieving weight loss or diuresis after 2 days of treatment with oral furosemide therapy. 2. Age > 1 year and less than 15 years.；
请登录查看1. Patients taking albumin therapy. 2. Nephrotic syndrome patient caretakers who will refuse to give consent 3. The patients who will achieve weight loss or diuresis within 2 days of treatment with oral furosemide therapy. Children < 1 year and >15 years with nephrotic syndrome admitted in our department fulfilling inclusion criterion.；
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54000
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