ChiCTR2500110542
尚未开始
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2025-10-15
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Cancer cervix
A Comparative study between Induction Chemotherapy Followed by Concurrent Chemoradiation versus Concurrent Chemoradiation in the Management of Locally Advanced Uterine Cervical Cancer
A Comparative study between Induction Chemotherapy Followed by Concurrent Chemoradiation versus Concurrent Chemoradiation in the Management of Locally Advanced Uterine Cervical Cancer
This study aims to explore the efficacy and tolerability of induction chemotherapy followed by chemoradiation versus conventional therapy chemoradiation in patients with locally advanced uterine cervical cancer.
随机平行对照
Ⅲ期
Randomization will be performed using a computer-generated random number table
Open-label
Sohag university
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40
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2025-10-12
2027-10-12
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1.Age between 18 and 70 years; 2.Clinically staged as IB3–IVA according to the International Federation of Gynecology and Obstetrics (FIGO); 3.Histologically proved squamous cell carcinoma or adenocarcinoma of the uterine cervix; 4.Performance status 0–2 according to Word Health Organization (WHO) criteria; 5.Normal hematological, renal and hepatic function.；
请登录查看1.Severe systemic or uncontrolled disease (infection, central nervous system, metabolic, etc.) that precluded the use of chemotherapy; 2.Pre-existing high grade neuropathy of any cause; 3.Histologically proved small cell carcinoma, leiomyosarcoma, lymphoma and other histopathologies other than Squamous cell carcinoma & adenocarcinoma; 4.Mental illness; 5.Previous or concomitant malignancies.；
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