ChiCTR2600125772
尚未开始
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2026-05-31
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Acne
Fractional Radiofrequency Microneedling Combined With Low-Dose Isotretinoin Versus Standard-Dose Isotretinoin in Moderate-to-Severe Acne A Randomized Controlled Pilot Study
Fractional Radiofrequency Microneedling Combined With Low-Dose Isotretinoin Versus Standard-Dose Isotretinoin in Moderate-to-Severe Acne A Randomized Controlled Pilot StudyFractional Radiofrequency Microneedling Combined With Low-Dose Isotretinoin Versus Standard-Dose Isotretinoin in Moderate-to-Severe Acne A Randomized Controlled Pilot Study
41002
To compare the efficacy of fractional RF microneedling combined with low-dose isotretinoin versus standard-dose isotretinoin monotherapy. To evaluate the safety of RF microneedling during concurrent isotretinoin therapy. To assess the impact of body mass index on treatment response. To examine the influence of lifestyle-related confounders on clinical outcomes
随机平行对照
其它
Randomization was done by a computer-generated permuted block randomization method (block size = 6).The research team used sealed envelopes, which they had prepared in sequential order, to conduct 1:1 patient randomization between the two treatment groups
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2026-05-30
2027-05-01
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The study included patients aged 18 to 33 years with moderate-to-severe acne vulgaris of the face, as defined by an Investigator Global Assessment (IGA) score of 3 or 4. All patients had failed or were unsuitable for conventional topical therapy alone. The study included patients aged 18 to 33 years with moderate-to-severe acne vulgaris of the face, as defined by an Investigator Global Assessment (IGA) score of 3 or 4. All patients had failed or were unsuitable for conventional topical therapy alone.；
请登录查看Patients were excluded from the study when they met any of these criteria: 1.They had used isotretinoin during the last 12 months; 2.They had documented hypersensitivity to retinoids; 3.They were currently suffering from active hepatic or renal or metabolic diseases; 4.Females were pregnant or they refused to follow birth control rules; 5.They had an existing skin infection at the sites where RF treatment was scheduled; 6.They had received RF microneedling treatment within the 6 months before their enrollment date.；
请登录查看University of Mosul
41002
汉氏联合2026-06-09
求实药社2026-06-09
肝脏时间2026-06-09
求实药社2026-06-09
求实药社2026-06-09
上海儿童医学中心2026-06-09
动脉网-最新2026-06-09
数字医疗2026-06-09
干细胞与外泌体2026-06-09
干细胞与外泌体2026-06-09
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