ChiCTR2600116305
尚未开始
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2026-01-08
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Chronic stress
靜觀課程對有慢性壓力的長者的微生物群成效研究: 隨機對照試驗
靜觀課程對有慢性壓力的長者的微生物群成效研究: 隨機對照試驗
Project Objectives (a maximum of 800 words in total for the project objectives) [Please list the objectives in point form] 1. To evaluate the efficacy of mindfulness-based training in enhancing gut microbiome diversity and beneficial bacteria in older adults with chronic stress. 2. To explore whether gut microbiota differences between MBOA and HEC are mediated by changes in mindfulness levels and moderated by perceived stress, depressive and anxiety symptoms, diet, sleep, and loneliness. Key issues and/or problems being addressed: Previous studies have shown that chronic stress is an important factor affecting gut microbiota composition and diversity, especially in older adults. Therefore, interventions designed to enhance the gut microbiota is most needed in older adults experiencing chronic stress. Mindfulness-based intervention is one of the candidates. Based on past studies, mindfulness-based interventions can effectively treat common mental health problems, including depression, chronic stress, and anxiety. However, there is limited evidence on its efficacy in enhancing gut microbiota and no randomized controlled studies have explored how it affects gut microbiota when compared to an active control. Therefore, this randomized control trial is designed to provide direct evidence for the impact of mindfulness-based interventions on gut microbiota in older adults. In addition, the moderating effects of perceived stress, depressive and anxiety symptoms, diet, sleep and loneliness will be explored, which will provide insight for the clinical application of mindfulness-based intervention.
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Stratified randomisation will be conducted based on age (5-year range) to achieve demographic balance between the two arms. An experienced independent statistician will generate the randomisation sequence using computer-generated random numbers.
The research staff member who conducts the assessments or statistical analyses will be blinded to the group assignments.
General Research Fund
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69
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2026-01-01
2027-12-31
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1. aged 60 or above; 2. being a Cantonese speaker; 3. having long-term care-giving responsibility for a first-degree relative with chronic condition; 4. scoring seven or above in the Caregiver Strain Index (CSI); 5. having no self-reported doctor’s diagnosis of psychiatric illnesses or impaired cognitive status.；
请登录查看1. having physical illness with moderate to-severe disability or mental illness (e.g., suicidal ideation, schizophrenia, psychosis) affecting his/her group enrolment; 2. under treatment for serious mental disorders or uncontrolled mood disorders; 3. participation in a structured mindfulness-based training program in the previous 2 years; 4. care recipients who had passed away before the study; 5. any use of antibiotics or probiotics in the past 6 months.；
请登录查看香港中文大學賽馬會公共衛生及基層醫療學院
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北京国际科技创新中心2026-01-09
良医汇肿瘤资讯2026-01-09
良医汇肿瘤资讯2026-01-09
广州日报2026-01-09
丁香园 Insight 数据库2026-01-09
首都医科大学2026-01-09
医学新视点2026-01-09
中国医药报2026-01-09
中国医药生物技术协会2026-01-09
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