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ChiCTR2500108583
尚未开始
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2025-09-02
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Chemotherapy-induced peripheral neuropathy in colorectal cancer patients
Effects of dance-based multimodal exercise programme for managing chemotherapy-induced peripheral neuropathy in patients with colorectal cancer: A randomized controlled study
Effects of dance-based multimodal exercise programme for managing chemotherapy-induced peripheral neuropathy in patients with colorectal cancer: A randomized controlled study
To examine the effects of a dance-based multimodal exercise programme when compared to usual care for the management of CIPN in CRC patients across the 3-month post-intervention period. The objectives include (1) To examine the effects of the programme on CIPN (primary outcome) at immediately, one-month and three-month post-intervention; and (2) To examine the effects of the programme on pain, balance, quality of life and anxiety (secondary outcomes) at immediately, one-month and three-month post intervention; and (3) To examine the effects of the programme on knowledge, motivation and self-efficacy of exercise (process outcomes) at immediately, one-month and three-month post intervention; and (4) To assess any adverse effects of the programme; and (5) To explore the perceived benefits, barriers and areas for improvement after participating the programme.
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CRC patients who are fulfilling the eligibility criteria and willing to participate in the programme will be randomized in 1:1 ratio after the baseline measurement. A computer-generated randomization list in a block of four is generated before the randomization. Allocation numbers are concealed in opaque sealed envelopes which only the principal investigator will open them and inform the participants about the program details.
An independent assessor will be blinded for the allocation of the participants and intervention.
Not applicable
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42;43
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2025-09-01
2026-08-31
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The inclusion criteria of participants include CRC patients who (1) have received or currently receiving more than one cycle of oxaliplatin-based chemotherapy; and (2) experience CIPN symptoms; and (3) are able to use smart phone and WhatsApp; and (4) are able to read or understand Chinese.；
请登录查看CRC patients will be excluded from this study when they (1) received neurotoxic chemotherapy other than oxaliplatin, including taxane-based chemotherapy, vinca alkaloids, proteasome inhibitors and thalidomide analogs; or (2) suffer from severe organ failure or diseases that limit their level of activity; or (3) are diagnosed with non-chemotherapy induced peripheral neuropathy, such as sciatica and diabetic neuropathy; or (4) receive treatments that affect the severity of neuropathy, such as steroid, anticonvulsants and antidepressants; or (5) age below 18 years old; or (6) have cognitive impairments.；
请登录查看The Nethersole School of Nursing, The Chinese University of Hong Kong
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