ChiCTR2500109058
尚未开始
/
/
/
2025-09-11
/
/
Mild Cognitive Impairment
A pilot study on the efficacy and safety of the use of a synbiotic formula (SCV09) in people with Mild Cognitive Impairment (MCI)
A pilot study on the efficacy and safety of the use of a synbiotic formula (SCV09) in people with Mild Cognitive Impairment (MCI)
1. To explore the efficacy and safety of a synbiotic formula (SCV09) in improving mood and cognitive symptoms in people with Mild Cognitive Impairment (MCI); 2. To explore the compositional and functional changes in the gut microbiome of people with MCI after treatment with SCV09.
单臂
其它
None
None
None
/
30
/
2025-09-22
2026-09-22
/
1.Chinese individuals aged between 60-85; 2.Mild cognitive impairment as determined by a Clinical Dementia Rating (CDR) = 0.5; 3.Hamilton Depression Rating Scale (HAM-D) >= 8, and that the mood symptoms occurred after MCI onset; 4.Having a family member or caregiver who could supervise the subject in taking the study products, collecting stool samples and attending the follow-up; 5.Able to provide informed consent.；
请登录查看1. Diagnosed with dementia, or already receiving drugs for dementia, such as cholinesterase inhibitors, memantine, and amyloid-targeting monoclonal antibodies; 2. Concomitant Parkinson’s disease and other neurodegenerative conditions affecting activities of daily living 3. Psychotic, suicidal, or treatment-resistant; 4. History of stroke; 5. History of severe organ failure (including decompensated cirrhosis), renal failure on ; dialysis, suffering from human immunodeficiency virus infection; 6. Pre-existing gastrointestinal diseases that significantly confound gut microbiota (eg, inflammatory bowel disease) 7. Confirmed active malignancy; 8. Known operations involving small intestines and large intestines; or history of appendectomy, hysterectomy, and cholecystectomy in the last 6 months; 9. Use of antipsychotics, antidepressants or sedatives, unless on a stable dose in the last 3 months; 10. Inability to receive oral fluids; 11. Use of antibiotics, probiotics or prebiotics in the last 2 weeks; 12. Intolerance to probiotics or lactose leading to a severe allergic reaction.；
请登录查看The Chinese University of Hong Kong
/
皮肤好医荟2025-12-04
体外诊断原料网2025-12-04
优赛生命2025-12-04
医药时间2025-12-04
佰傲谷BioValley2025-12-04
求实药社2025-12-04
启迪之星2025-12-04
亚虹医药2025-12-04
幂方健康基金2025-12-04
汉氏联合2025-12-04
400-9696-311 转1
400-9696-311 转2
400-9696-311 转3
400-9696-311 转4
浙公网安备33011002015279
本网站未发布麻醉药品、精神药品、医疗用毒性药品、放射性药品、戒毒药品和医疗机构制剂的产品信息
友情链接: 摩熵医药 摩熵医药企业版 摩熵化学MolAid 晓材Matmole 摩熵医学MedXYZ 载体质粒 觅健肿瘤互助 动脉网 药物百科 中国医疗人才网 医药招商网
