ChiCTR2600119373
尚未开始
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2026-02-26
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Colorectal cancer
The efficacy of Tai Chi on the microbiome of patients with colorectal cancer: A pilot randomized controlled trial
The efficacy of Tai Chi on the microbiome of patients with colorectal cancer: A pilot randomized controlled trial
The objective of this study is to examine the feasibility and preliminary efficacy of a 12-week Tai Chi intervention in improving gut microbiota diversity among patients with colorectal cancer at 12-week and 24-week follow-ups compared with a self-managed control group.
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The random number sequence will be generated by an independent biostatistician using computer-generated block randomization with randomly varied block sizes between 6 and 12, stratified by primary cancer treatment (targeted therapy versus non-targeted therapy). The allocation sequence will be maintained by the biostatistician and will not be accessible to the research team members involved in participant recruitment or assessment to ensure allocation concealment.
All research team members, except for the research assistant responsible for informing participants of their group allocation, will be blinded to group assignment. Outcome assessments will be conducted by research assistants who are blinded to allocation. Tai Chi instructors will not be informed of the study design and will not be involved in outcome assessment. Due to the nature of the behavioral intervention, participants cannot be blinded.
Not applicable
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29
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2026-03-01
2027-12-31
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1. Diagnosed with colorectal cancer confirmed by pathology, with no other cancer diagnosis within the previous year. 2. Karnofsky Performance Status (KPS) score >=70. 3. Aged 18 years or above. 4. Able to communicate in Cantonese or Mandarin. 5. Conscious and alert.；
请登录查看1. Somatic conditions that limit participation in exercise (e.g., limb loss, severe balance or postural instability, serious cardiopulmonary limitation, neurological or sensory deficits). 2. Current participation in any behavioral trial or instructor-led exercise program. 3. Regular practice of physical activity defined as >=150 minutes of moderate-intensity physical activity per week.；
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