ChiCTR1900026182
结束
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2019-09-25
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Hematological disorders of the spleen
Rolul miRNA in modelarea imuna dupa splenectomia totala si partiala.
Rolul miRNA in modelarea imuna dupa splenectomia totala si partiala.
As part of the SPLENIMUN study we analysed the impact of total vs. subtotal splenectomy (by open or minimally invasive approach) in spherocytosis. Hereditary spherocytosis (HS) is a common inherited disease affecting the erythrocyte membrane. Splenectomy is effective in reducing hemolysis and decreasing the need of transfusions, but total removal of the spleen represents a potential risk factor for infectious and non-infectious complications. On the other hand, subtotal splenectomy, could be an alternative therapy in HS. The aim of this study is to establish which surgical approach has the best outcome in hereditary spherocytosis.
析因分组（即根据危险因素或暴露因素分组）
回顾性研究
N/A
N/A
Public Founding
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21;42
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2013-01-01
2016-12-31
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Patients with moderate to severe anemia and recurrent blood transfusions that required splenectomy.；
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