ChiCTR2000040213
结束
/
/
/
2020-11-25
/
/
Chronic ankle instability
Clinical Effectiveness of Hypertonic Dextrose Prolotherapy in Chronic Ankle Instability: A Randomized Clinical Trial
Clinical Effectiveness of Hypertonic Dextrose Prolotherapy in Chronic Ankle Instability: A Randomized Clinical Trial
The primary aim of this study is to assess the clinical effectiveness of DPT versus normal saline in improving the self-reported functional ankle instability among individuals with CAI in one-year period. Our secondary aims are to evaluate the objective ankle function, quality of life, incidents of recurrent ankle sprain and cost-effectiveness.
随机平行对照
Ⅱ期
Randomization will be done in a 1:1 ratio using the Random Allocation Software by a statistician.
Double-blind
There was no funding support for this study.
/
57
/
2020-12-01
2024-12-30
/
The inclusion criteria include age >=18 years old, with a diagnosis of CAI, defined as having at least 1 significant ankle sprain, and at least 2 episodes of giving way in the 6 months prior to study enrollment ,and a Cumberland Ankle Instability Tool (CAIT) score <=24. Clinically confirmed lateral ankle laxity with positive anterior drawer test (anterior talofibular ligament involvement) and ultrasound confirmed ATFL laxity by the length change of ATFL under stress ( maximum anterior draw position) and at rest >20%.；
请登录查看The exclusion criteria include acute ankle sprain <=6 months; complete tear of ATFL confirmed by USG or MRI; a history of previous surgeries to the musculoskeletal structures (ie, bones, joint structures, nerves) in either lower extremity; acute injury to musculoskeletal structures of other joints of the lower extremity in the previous 3 months that impacted joint integrity and function (ie, sprains, fractures), resulting in at least 1 interrupted day of desired physical activity; a history of a fracture in either lower extremity requiring realignment; high ankle sprain, generalized ligament laxity; pregnancy; on anti-coagulant therapy; prior ATFL or ankle injections within 3 months; inflammatory or post-infectious ankle arthritis, such as clinically diagnosed rheumatoid arthritis, gouty arthritis, psoriatic arthritis and septic arthritis; history of corn allergy and co-morbidity or lifestyle preventing participation in the study protocol.；
请登录查看The Chinese University of Hong Kong
/
医药经济报2025-12-12
医学新视点2025-12-12
上海拓界生物医药2025-12-12
绽妍JUYOU2025-12-12
隆门资本2025-12-12
信邦制药2025-12-12
君实医学2025-12-12
触界生物2025-12-12
标新生物GLUETACS2025-12-12
兽药资讯2025-12-12
400-9696-311 转1
400-9696-311 转2
400-9696-311 转3
400-9696-311 转4
浙公网安备33011002015279
本网站未发布麻醉药品、精神药品、医疗用毒性药品、放射性药品、戒毒药品和医疗机构制剂的产品信息
友情链接: 摩熵医药 摩熵医药企业版 摩熵化学MolAid 晓材Matmole 摩熵医学MedXYZ 载体质粒 觅健肿瘤互助 动脉网 药物百科 中国医疗人才网 医药招商网
