ChiCTR-TRC-14004215
尚未开始
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2014-01-28
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Intermittent Claudication in Patients with Peripheral Arterial Disease
丹參葛根膠囊治療間隔性跛行伴外周動脈疾病的臨床研究
丹參葛根膠囊治療間隔性跛行伴外周動脈疾病的臨床研究
To determine a novel Treatment of Intermittent Claudication in Patients with Peripheral Arterial Disease Using Traditional Chinese Medicine.
随机平行对照
Ⅳ期
RCT
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Health Medical Research Fund
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226
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2014-07-04
1990-01-01
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Men and women 40 years or older; at least 3-month history of stable IC (Rutherford class 2 or 3) secondary to lower extremity PAD; PAD defined as resting ABI <0.90 in at least 1 limb and a >=10mmHg decrease in ankle artery blood pressure after exercise. In patients with non-compressible vessels (ABI >1.50), the toe–brachial index (TBI) at rest has to be <0.70; Reproducible walking distances with <25% variance between 2 baseline treadmill tests and who terminated all screening treadmill tests solely because of IC pain；
请登录查看Critical limb ischemia defined by ischemic rest pain, ulceration, or gangrene (Rutherford class >=4); Major lower limb amputation (above or below knee amputation); Surgical or endovascular revascularization for PAD within 3 months; Exercise limitation due to significant concomitant disease (e.g. severe hip or knee arthritis, coronary artery disease, heart failure, chronic obstructive airway disease); Concomitant anticoagulation therapy (e.g. warfarin); Pregnancy or breastfeeding; Unable to complete the screening and follow-up treadmill protocols.；
请登录查看Department of Medicine & Therapeutics, The Chinese University of Hong Kong
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