【ChiCTR1900025199】Changes in HOMA-IR Index Levels After Bariatric Surgery: Comparison of Single Anastomosis Duodenal Switch (SADS) and One Anastomosis Gastric Bypass (OAGB-MGB)
ChiCTR1900025199
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2019-08-16
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肥胖
Changes in HOMA-IR Index Levels After Bariatric Surgery: Comparison of Single Anastomosis Duodenal Switch (SADS) and One Anastomosis Gastric Bypass (OAGB-MGB)
Changes in HOMA-IR Index Levels After Bariatric Surgery: Comparison of Single Anastomosis Duodenal Switch (SADS) and One Anastomosis Gastric Bypass (OAGB-MGB)
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Bariatric surgery plays a major role in ameliorating metabolic abnormalities of type 2 diabetes (T2DM). The aim of this study was to evaluate the early effects of “Single Anastomosis Duodenal Switch-proximal approach” (SADS-p) and “One Anastomosis Gastric Bypass-Mini Gastric Bypass (OAGB-MGB) on the “homeostasis model assessment of insulin resistance” (HOMA-IR) index levels in morbidly obese patients with T2DM.
连续入组
回顾性研究
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N/A
own funding
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260
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2017-05-29
2018-07-16
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The study was performed according to the principles of the Helsinki Declaration. Ethics Committee of Ankara Liv Hospital approved the study. In this retrospective, parallel group trial, all patients were evaluated for bariatric surgery by a multidisciplinary team of a surgeon, an endocrinologist, a psychologist, dietitian and an anesthesiologist. Two hundred and sixty morbidly obese patients (Body Mass Index>40kg/m2 or Body Mass Index>35kg/m2 + two co-morbidities) who underwent OAGB-MGB (n=200) and SADS-p (n=60) were included in the study. Patients requiring revisional surgery were excluded from the study. Both surgical techniques were described in detail to the patients. Surgical technique was selected considering the presence of T2DM, body mass index (BMI), eating habits, and requests of the patients. Fasting insulin (FI), fasting blood glucose (FBG), HbA1c, “homeostasis model assessment of insulin resistance” (HOMA-IR index), excess weight loss (EWL), and BMI, body weight were collected before surgery and at 1, 3, 9, 12 months after surgery. HOMA-IR index was calculated from FBG and FI levels.；
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