【ChiCTR1900027029】Structured frontal lobe based cognitive stimulation to older adults with depressive symptoms but without dementia or mild cognitive impairment
ChiCTR1900027029
尚未开始
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2019-10-29
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depressive symptoms
Structured frontal lobe based cognitive stimulation to older adults with depressive symptoms but without dementia or mild cognitive impairment
Structured frontal lobe based cognitive stimulation to older adults with depressive symptoms but without dementia or mild cognitive impairment
1. to test whether cognitive stimulation can improve depressive symptoms in older adults who are still cognitively relatively normal; 2. to test whether the improvement in depressive symptoms can be explained by changes in cognitive performance, inflammatory response, and BDNF level
随机抽样
Ⅱ期
In the randomization procedure, each participant will be assigned a special code generated by a computer. The statistician of the department will perform all the randomization and will not be involved in enrollment or outcome assessment.
Open label
Direct Grant for Research 2018/2019
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30
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2019-11-01
2020-12-31
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Community-living Chinese individuals aged 55 to 75 years old with subjective cognitive decline and comorbid depressive symptoms will be recruited through elderly social centres in Hong Kong；
请登录查看non-Chinese ethnicity; living in care homes; having history of stroke, traumatic brain injury, Parkinson’s disease, MCI, or clinical dementia; scoring Hong Kong Chinese version of Montreal Cognitive Assessment (HK-MoCA) ≤25 (i.e. the cutoff score for MCI in young old with high educational level); taking drugs that affect cognition (e.g. benzodiazepines, anti-dementia medication, etc.); having history of bipolar affective disorder, psychosis, or substance abuse; already attending other cognitive or psychological intervention programs; and having significant impairments in vision, hearing or communication；
请登录查看Faculty of Medicine, Chinese University of Hong Kong
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